产品货号：
Z14029
中文名称：
DIO1抗体
英文名称：
Anti-DIO1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-DIO1 Antibody |
| 指标别名 | 5DI,DIO1,DIOI,ITDI1,TXDI1,Type 1 DI,Type I 5 deiodinase |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,ICC/IF,FCM,ELISA |
| 基因名称 | DIO1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human DIO1 recombinant protein (Position:K137-S249). |
| 实际分子量 | 29KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Type I iodothyronine deiodinase is a protein that in humans is encoded by the DIO1 gene.It is mapped to 1p32.3.The protein encoded by this gene belongs to the iodothyronine deiodinase family.It catalyzes the activation,as well as the inactivation of thyroid hormone by outer and inner ring deiodination,respectively.The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine,T4),secreted by the thyroid gland,to the bioactive thyroid hormone (3,5,3'-triiodothyronine,T3) by 5'-deiodination.This protein provides most of the circulating T3,which is essential for growth,differentiation and basal metabolism in vertebrates.This protein is a selenoprotein,containing the rare amino acid selenocysteine (Sec) at its active site.Sec is encoded by the UGA codon,which normally signals translation termination.The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure,designated the Sec insertion sequence (SECIS) element,that is necessary for the recognition of UGA as a Sec codon,rather than as a stop signal.Alternatively spliced transcript variants have been found for this gene. |
| Uniprot ID | P49895 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | iodothyronine deiodinase 1 |
| 蛋白名全称 | Type I iodothyronine deiodinase |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (ELISA)： 1:100～1000 |
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